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pentobarbital will lessen the extent or outcome of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Watch Intently (one)pentobarbital will decrease the extent or result of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Loss of, or diminished response to tofac